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Horm Metab Res 1978; 10(4): 340-343
DOI: 10.1055/s-0028-1093427
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© Georg Thieme Verlag KG Stuttgart · New York

Cyclic AMP Mediated Increased Amino Acid Transport: Effect of Isoproterenol Administration

D.  Malamud , H.  Chiu
  • Department of Biochemistry, University of Pennsylvania, School of Dental Medicine, Philadelphia, Penn. 19104, U.S.A.
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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

A single injection of isoproterenol (IPR) stimulates cell proliferation in rodent salivary glands after a lag period of about 24 hrs. Among the many events occurring prior to stimulated DNA synthesis, there is an early increase in cAMP levels and elevated transport of amino acids into the parotid gland. Amino acid transport is also elevated in liver and pancreas, tissues not induced to proliferate by IPR. IPR-stimulated α-aminoisobutyric acid (AIB) transport in parotid, pancreas and liver is augmented by prior injection of theophylline and is mimicked by dibutyryl cAMP. In all three tissues, changes in cAMP levels and subsequent increases in AIB transport appear to be closely related events. Since only the parotid gland is stimulated to grow after IPR injection, amino acid transport and growth would not appear to be directly related.

Key words

cAMP - Parotid - Amino Acid Transport