This study aimed to examine the possibility that ethanol-induced rise of serum triglyceride concentration in man is partly due to an impaired removal of triglycerides from the circulation. Acute ethanol loads given to normal human subjects after an overnight fast reduced the post heparin plasma lipoprotein lipase activity by an average of 25 % but did not influence the postheparin plasma hepatic lipase activity or fractional removal of Intralipid triglyceride. When alcohol was administered to fed subjects in the evening the postheparin plasma hepatic lipase was significantly decreased in the next morning as compared to corresponding control value but the lipoprotein lipase and Intralipid clearance were not changed.
It is concluded that the slight decrease of lipoprotein lipase during alcohol intoxication may contribute to the hyperlipemic effect of ethanol.
Ethanol - Alcohol - Postheparin Plasma - Lipoprotein Lipase - Hepatic Lipase - Fat Tolerance
