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Horm Metab Res 1978; 10(2): 117-123
DOI: 10.1055/s-0028-1093456
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© Georg Thieme Verlag KG Stuttgart · New York

Pancreatic Hormones and Plasma Glucose: Regulation Mechanisms in the Goose under Physiological Conditions - II. Glucose-Glucagon and Glucose-Insulin Feed-Back Mechanisms

G.  Sitbon , P.  Mialhe
  • Laboratoire de Physiologie Generale - Universite Louis Pasteur - Strasbourg-France, CNRS, ERA 188 and INSERM contrat 75.1.051.4., France
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

We have studied the pancreatic hormone-glucose feed-back mechanisms by infusing glucagon (G), insulin (I) and glucose into normal fasting geese. The controls received saline.

Whilst a NaCl 9% infusion is devoid of effect, the pancreatic hormones, used at physiological doses, modify the plasma glucose level, glucagon being hyperglycemic and insulin hypoglycemic.

In addition, a physiological increase in plasma glucose provokes a drop in plasma glucagon and a rise in plasma insulin, thus a marked decrease in the G/I ratio.

The results show that the pancreatic hormone-glucose feedback mechanisms are effective under physiological conditions.

Key words

Goose - Physiological Conditions - Feed-Back - Glucose - Glucagon - Insulin - G/I Ratio