Regulation of Pyruvate Dehydrogenase by Ca2+, 3'5' Cyclic AMP and Adrenalin in Isolated Rat Kidney Tubules

D. W. R. Macdonald; E. D. Saggerson

doi:10.1055/s-0028-1093459

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Horm Metab Res 1978; 10(2): 135-138
DOI: 10.1055/s-0028-1093459

Originals

Regulation of Pyruvate Dehydrogenase by Ca²⁺, 3'5' Cyclic AMP and Adrenalin in Isolated Rat Kidney Tubules

D.W. R. Macdonald , E. D. Saggerson

Department of Biochemistry, University College London, U.K.

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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Renal pyruvate dehydrogenase_a activity was measured in suspensions of kidney cortex tubules from fed rats after incubation with various concentrations of Ca²⁺, 3'5' cyclic AMP or adrenalin. At certain concentrations these agents all decreased pyruvate dehydrogenase_a activity and increased glucose formation from pyruvate. There appeared to be some interdependence between the effects of Ca²⁺ and 3,5, cyclic AMP on pyruvate dehydrogenase_a activity. Effects of adrenalin on pyruvate dehydrogenasea activity were no longer observed when palmitate was included in incubations. The possibility that regulation of pyruvate dehydrogenase_a may indirectly contribute to the control of gluconeogenesis by influencing pyruvate metabolism is briefly discussed.

Key words

Adrenalin - Calcium - 3'5 Cyclic AMP - Glucogenogenesis - Pyruvate Dehydrogenase - Renal Cortex