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Horm Metab Res 1978; 10(1): 46-49
DOI: 10.1055/s-0028-1093479
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© Georg Thieme Verlag KG Stuttgart · New York

Epinephrine-Sensitive Adenylate Cyclase of Human Fat Cell Ghosts

Modulation of Enzyme Activity by GTPH.  Kather , K.  Zöllig , B.  Simon
  • Klinisches Institut für Herzinfarktforschung an der Medizinischen Universitätsklinik Heidelberg, Germany (Director: Prof. Dr. Dr. h.c. G. Schettler)
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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

Some of the effects of GTP on human fat cell adenylate cyclase activity were studied. This nucleotide caused a dosedependent inhibition of basal activity without affecting the hormone-activated rate of cAMP formation. Maximal effects were observed at GTP-concentrations of about 1×10-4M. The relative extent of hormonal stimulation was about 1.5-fold increased in the presence of 0.1 mM GTP.

Key words

Adenylate Cyclase - Epinephrine - GTP - Human Adipose Tissue