Metabolism of Thyroid Hormones by the Isolated Perfused Rabbit Kidney

Abstract

The metabolism of thyroxine and triiodothyronine in the isolated perfused rabbit kidney was monitored by specific radioimmunoassay for each hormone. The amount of thyroxine catabolised was proportional to the amount added initially and no saturation effects were observed over a wide range (3.9-82 nmol).

After addition of thyroxine alone, triiodothyronine could be detected in the perfusion medium within 10 minutes but only much later in the urine. It was proposed that circulating thyroxine contributes indirectly to the level of urinary triiodothyronine.

Key words

Kidney Perfusion - Thyroxine - Triiodothyronine - Metabolism of Thyroid Hormones

1 Present address: Klinikum Steglitz der Freien Universität Berlin, Endokrinologische Abteilung, Medizinische Klinik und Poliklinik, Hindenburgdamm 30, 1000 Berlin 45, West Germany