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Horm Metab Res 1977; 9(6): 441-443
DOI: 10.1055/s-0028-1093496
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© Georg Thieme Verlag KG Stuttgart · New York

Failure of Exogenous Insulin to Inhibit Insulin Secretion in Man

K.  Shima , S.  Morishita , N.  Sawazaki , R.  Tanaka , S.  Tarui
  • The Department of Medicine and Geriatrics, The Second Department of Internal Medicine, Osaka University Medical School, Osaka, Japan
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Publication Date:
23 December 2008 (online)

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Abstract

In order to explore whether or not the negative feedback mechanism of insulin per se on insulin secretion exists in man, changes in plasma C-peptide immunoreactivity (CPR), as an index of pancreatic B cells secretory function, were studied in 6 nonobese healthy volunteers in the presence of high circulating levels of exogenous insulin. 10% glucose was infused concurrently so as to maintain blood sugar at the basal level. The insulin-glucose infusion was maintained for 120 minutes, achieving mean plasma levels of 140-180 µU/ml. After this period, the insulin infusion was continued at the same rate for an additional 10 minutes while the glucose was omitted.

Despite the elevated level of circulating insulin, no significant change in plasma CPR concentration was observed so long as the blood sugar was maintained at the basal levels. Following cessation of the glucose infusion, the plasma CPR levels declined with a decrease in blood sugar level.

Under the conditions of the present study, no inhibitory effect of exogenous insulin on the secretory function of the B cells was noticed.

Key words

C-peptide - Insulin - Secretion - Blood Glucose

1 Some parts of this paper were read at International Congress of Endocrinology, 18-24, July 1976, Hamburg. Supported by a Grant-in-Aid for Developmental Scientific Research from the Education Ministry, No. 057172.