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Horm Metab Res 1977; 9(6): 474-480
DOI: 10.1055/s-0028-1093503
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© Georg Thieme Verlag KG Stuttgart · New York

Decreased Sensitivity to Insulin in White Adipose Tissue from Adrenalectomised Rats

S. J. Smith [*] , E. D. Saggerson
  • Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, U.K.
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

The ability of insulin to increase both [14C|-glucose incorporation into fatty acids and pyruvate dehydrogenasea activity in incubated rat epididymal adipose tissues was considerably lessened after adrenalectomy. Insulin antagonism of adrenaline-stimulated lipolysis in isolated fat cells was abolished after adrenalectomy. Percentage stimulation of lipolysis above basal by adrenaline was not appreciably altered by adrenalectomy.

Key words

Adipose Tissue - Adrenalectomy - Adrenaline - Fatty Acid Synthesis - Insulin - Lipolysis - Pyruvate Dehydrogenase

1 Present address: Department of Biophysics, Kings' College, Drury Lane, London W.C.I.