Hormone and Metabolic Research, Table of Contents Horm Metab Res 1977; 9(6): 474-480DOI: 10.1055/s-0028-1093503 Originals © Georg Thieme Verlag KG Stuttgart · New York Decreased Sensitivity to Insulin in White Adipose Tissue from Adrenalectomised Rats S. J. Smith [*] , E. D. Saggerson Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, U.K. Recommend Article Abstract PDF Download Buy Article Abstract The ability of insulin to increase both [14C|-glucose incorporation into fatty acids and pyruvate dehydrogenasea activity in incubated rat epididymal adipose tissues was considerably lessened after adrenalectomy. Insulin antagonism of adrenaline-stimulated lipolysis in isolated fat cells was abolished after adrenalectomy. Percentage stimulation of lipolysis above basal by adrenaline was not appreciably altered by adrenalectomy. Key words Adipose Tissue - Adrenalectomy - Adrenaline - Fatty Acid Synthesis - Insulin - Lipolysis - Pyruvate Dehydrogenase PDF (242 kb) References 1 Present address: Department of Biophysics, Kings' College, Drury Lane, London W.C.I.
