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Horm Metab Res 1977; 9(6): 492-494
DOI: 10.1055/s-0028-1093507
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Metoclopramide on Prolactin Secretion in Man

F.  Minuto , M.  Marugo , M.  Giusti , M.  Baiardi , G.  Giordano
  • Istituto Scientifico di Medicina Interna dell'Universita di Genova, Cattedra di Endocrinolgia, Italy
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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

Prolactin (PRL) secretion was studied after i.m. administration of Metoclopramide (alone or with a pre treatment with 5-Br-2α-ergo-cryptine) and after i.m. administration of Sulpiride.

The results obtained evidenced a considerable hPRL increase after Metoclopramide administration, similar to that observed with Sulpiride, completely abolished by 5-Br-2α-ergocryptine.

On the basis of these data it seems evident a strong and specific effect of Metoclopramide on hPRL secretion, probably more potent than Sulpiride.

Key words

Prolactin (PRL) - Metoclopramide - Sulpiride - Bromocryptine