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Horm Metab Res 1977; 9(5): 366-370
DOI: 10.1055/s-0028-1093529
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© Georg Thieme Verlag KG Stuttgart · New York

Insulin and Glucagon: Plasma Levels and Pancreatic Release in the Genetically Obese Zucker Rat

G. F. Bryce1 , Patricia R. Johnson2 , Ann C. Sullivan3 , Judith S. Stern4
  • 1Department of Cell Biology, Roche Research Center, Nutley, New Jersey, U.S.A.
  • 2Department of Biology, Vassar College, Poughkeepsie, New York, U.S.A.
  • 3Department of Biochemical Nutrition, Roche Research Center, Nutley, New Jersey, U.S.A.
  • 4The Rockefeller University, New York City, New York, U.S.A.
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Circulating levels of insulin and glucagon, as well as their release from isolated pancreatic islets, have been measured in Zucker rats to examine the effect of genotype, sex and diet. The obese animals had higher plasma insulin levels and enhanced release from islets when compared to lean controls. Conversely, obese animals, despite no significant differences in fed plasma levels of glucagon, showed substantially reduced release from islets. Diet had no main effect on any of these parameters.

Key words

Insulin - Glucagon - Circulating Levels - Pancreatic Islets - Zucker Rats