Effect on Pancreatic Blood Flow and Insulin Output of Infusions of Aminophylline, Galactose and Galactose plus Aminophylline into an Isolated In Situ Portion of Pancreas

Abstract

Effects on pancreatic blood flow and insulin output of infusions of aminophylline, galactose and galactose plus aminophylline were studied on an isolated portion of dog pancreas with only one afferent and one efferent blood vessel remaining. Infusion of aminophylline at 8 mg per minute gave significant increases in pancreatic blood flow and insulin output. Infusion of galactose at 7.2 mg per minute significantly increased insulin output. Galactose (7.2 mg per minute) plus aminophylline (8 mg per minute) also increased both pancreatic blood flow and insulin output. Pancreatic venous plasma glucose levels rose slightly during these infusions. Since the perfusing plasma contained a fasting level of glucose, both aminophylline and galactose when infused alone or together were infused in the presence of approximately 1 mg/ml glucose. Pancreatic blood flow and insulin output increased to a lesser extent when aminophylline was infused along with galactose, than when aminophylline was infused alone.

Key words

Pancreatic Blood Flow - Insulin Secretion - Plasma Glucose - Aminophylline - Galactose