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Horm Metab Res 1977; 9(2): 132-136
DOI: 10.1055/s-0028-1093561
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© Georg Thieme Verlag KG Stuttgart · New York

Alterations of the Glycolytic Pathway and Adenine Nucleotide State in Livers of Clofibrate Treated Rats

J.  Wilkening , P.  Schwandt
  • Medizinische Klinik II, Klinikum Großhadern, Universität München, Germany
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Publication Date:
23 December 2008 (online)

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Abstract

The influence of Clofibrate on the glycolytic pathway in liver was studied. The changes in the activity of glucokinase and hexokinase were not significant. A reduction of phosphofructokinase (p < 0.05) and pyruvate kinase activity was found (p < 0.0005) during Clofibrate feeding. An in vitro inhibition of these enzymes could not be demonstrated by Clofibrate up to a concentration of 2.5 mM. Crossover plots of glycolytic intermediates indicate that the reduced pyruvate kinase activity may influence the glycolytic pathway in vivo. Clofibrate feeding induces a lower ATP:ADP ratio, a lower adenylate energy charge and elevates AMP levels in rat liver. This may possibly stimulate the hepatic glycogenolysis and the glucose utilisation by this organ.

Key words

Glycolytic Pathway - Adenine Nucleotides - Rat Liver - Clofibrate