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Horm Metab Res 1977; 9(2): 150-152
DOI: 10.1055/s-0028-1093565
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© Georg Thieme Verlag KG Stuttgart · New York

Suppression of ACTH Secretion by Synthetic MSH-Release Inhibiting Factor PRO-LEU-GLY-NH2 in Addison's Disease[*]

K. H. Voigt1 , H. L. Fehm2 , R. E. Lang2 , K. E. Beinert2 , E. F. Pfeiffer2
  • 1Department of Physiology[*], University of Ulm, Germany
  • 2Department of Internal Medicine, Endocrinology and Metabolism, University of Ulm, Germany
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

The regulation of release of MSH and ACTH seems to be closely related. The effect of Pro-Leu-Gly-NH2, the most active MSH-release inhibiting factor (MIF), was investigated on ACTH-hypersecretion in six patients suffering from primary adrenocortical insufficiency. MIF was infused at constant rates with stepwise increase in concentration (0.25 mg, 2.5 mg, 25.0 mg/30 min). Plasma ACTH-levels were measured radioimmunologically at 10 minutes intervals. In four cases there was a remarkable decrease (P < 0.005) in the ACTH plasma level of more than 50% as compared to the elevated starting levels of 800 to 1400 pg/ml.

It is concluded that under certain circumstances MIF could play a role in the regulation of ACTH-secretion.

Key words

MSH-Release Inhibiting Factor (MIF) - ACTH Secretion - Addison's Disease

1 Supported by the Deutsche Forschungsgemeinschaft (SFB 87/B2)

1 Supported by the Deutsche Forschungsgemeinschaft (SFB 87/B2)