PDF herunterladen
Horm Metab Res 1977; 9(1): 13-16
DOI: 10.1055/s-0028-1093575
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Prolonged Intravenous Infusions of LH-Releasing Hormone into Normal Men

W. J. Bremner [*] , C. A. Paulsen
  • Division of Endocrinology, Department of Medicine, University of Washington School of Medicine and
    Division of Endocrinology, U.S. Public Health Service Hospital, Seattle, Washington, U.S.A.
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
23. Dezember 2008 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Abstract

Five normal men received constant intravenous infusions of luteinizing hormone-releasing hormone (LH-RH), 0.2 µg/min, for 14-19 hours. Serum levels of luteizining hormone (LH) revealed a biphasic pattern of increase, reaching maximal values by 4 hours after the infusions began, then remained near that level until the infusions ceased. Serum follicle stimulating hormone (FSH) levels rose gradually to maximal values by 6-13 hours and maintained this level until the end of the infusions. Testosterone (T) levels revealed gradual increases throughout the infusions.

These results confirm an increase in serum T levels with prolonged endogenous gonadotrophin stimulation. This is in contrast to the inability of several previous studies to demonstrate an increase in T levels following the relatively short gonadotrophin elevation produced by single-shot LH-RH administration. The T increases produced, however, were quantitatively much less than those reported during prolonged LH-RH infusions in rams, suggesting that the human testis is less responsive to endogenous gonadotrophin stimulation than is that of the ram. In addition, prolonged LH-RH stimulation did not cause pituitary refractoriness in men as has been described in animals.

Key words

LHRH - LH - FSH - Testosterone - Normal Man

1 Present address: Medical Research Centre, Prince Henry's Hospital, St. Kilda Road, Melbourne, Victoria, Australia, 3004.