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Horm Metab Res 1977; 9(1): 40-46
DOI: 10.1055/s-0028-1093581
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© Georg Thieme Verlag KG Stuttgart · New York

Intrahepatic Transplantation of Pancreatic Islets in the Rat[*]

Rosy  Eloy , Michèle  Kedinger , J. C. Garaud , Katy  Haffen , J. F. Launay , J.  Moody1 , G.  Clendinnen , A. F. Grenier
  • Unit of Surgical Research and Biophysiopathology of the Intestine, U. 61 INSERM, Strasbourg-Hautepierre (France)
  • 1Novo Research Institute, Copenhagen (Denmark)
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Islets of Langerhans from isogeneic donor rats were transplanted directly into the hepatic parenchyma of recipients which had been made severely diabetic by streptozotocin (glycaemia ranging between 400 and 1090 mg%). Complete control lasting up to 13 months was achieved in 65% of recipients by using 600-800 islets. Following intravenous glucose administration, each rat responded similarly to normal rats with a rapid but reduced release of insulin. Cytoimmunofluorescence and electron microscopic studies demonstrated the presence of both functional insulin and glucagon cells, within the transplanted islets. It is suggested that for various reasons direct intrahepatic transplantation might become the preferred method for islets.

Key words

Diabetes - Pancreatic Transplantation - Isolated Langerhans Islets

1 This work was supported by INSERM - Grant no. 75.50207.

1 This work was supported by INSERM - Grant no. 75.50207.