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Horm Metab Res 1976; 8(5): 399-401
DOI: 10.1055/s-0028-1093603
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© Georg Thieme Verlag KG Stuttgart · New York

Diphenylhydantoin Inhibition of Pentagastrin-Stimulated Calcitonin Secretion in the Pig

J. T. Pento
  • Department of Pharmacology, University of Oklahoma, Norman, Oklahoma, USA
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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

The present study examined the influence of diphenylhydantoin (DPH) on pentagastrin-induced calcitonin (CT) secretion in the pig. Diphenylhydantoin was observed to slow the onset and prolong the duration of pentagastrin stimulation on CT secretion. Further, pentagastrin reduced plasma calcium in both the control and DPH treated groups. The results of this study indicate a significant DPH-induced inhibition of pentagastrin-stimulated CT secretion in the pig.

Key words

Calcitonin Secretion - Diphenylhydantoin - Pentagastrin - Calcium