Abstract
Clomiphene (10-3 - 10-2 M) in a dose-dependent manner inhibited the lypolytic response of isolated rat epididymal adipose tissue and fat cells to epinephrine, ACTH, and dibutyryl-cyclic AMP. Furthermore, it reduced the non-hormonally stimulated activity of a crude preparation of lipase from epididymal adipose tissue. The accumulation of cyclic AMP produced by epinephrine in fat cells was not prevented by clomiphene at a concentration causing antilipolytic activity. It is concluded from these results that clomiphene unlike most other antilipolytic drugs exerts its antilipolytic effect by an inhibition of the lipase rather than by inhibition of adenylcyclase.
Key words
Lipolysis - Cyclic AMP - Clomiphene - Epinephrine - ACTH
1 The results have been presented at the Symposium of the Deutsche Gesellschaft für Endokrinologie, Tübingen 1974 and on the Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz 1974.
