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Horm Metab Res 1976; 8(2): 97-101
DOI: 10.1055/s-0028-1093680
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© Georg Thieme Verlag KG Stuttgart · New York

Islet Transplantation in Experimental Diabetes of the Rat

IV. The Influence of Transplantation Site and of Histocompatibility on Islet FunctionK.  Federlin [*] , M.  Slijepčević [**] , K.  Helmke
  • Division of Clinical Immunology, Center of Internal Medicine and Pediatrics, University of Ulm, Germany
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Experimental islet transplantations in pancreatectomized and streptozotocin-treated diabetic allogeneic and partially inbred rats are considered with respect to transplantation site and immunological factors responsible for survival. It could be shown that transplantation into the liver and into the lung in both systems (allogeneic and partially inbred) was accompanied by longer survival of the islets compared with the following regions: subcutaneous tissue, muscle, epididymal fat tissue, peritoneal cavity.

This indicates that not only immunological but also factors of blood supply (oxygen consumption? ) play a role in the survival of the grafts. - The success of transplantation depends mainly on histocompatibility. Partially inbred rats showed significantly longer survival of islets than non-inbred rats. The studies of other groups using similar experimental models are reviewed.

Key words

Experimental Diabetes - Streptozotocin - Pancreatectomy - Islet Transplantation - I. V. Glucose Tolerance Test - Survival Period - Histocompatibility

1 Supported by Deutsche Forschungsgemeinschaft SFB 87 Grand (D) 7 Ulm

2 Institute "Rudjer Bošković", Zagreb, Yugoslavia