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Horm Metab Res 1975; 7(6): 488-491
DOI: 10.1055/s-0028-1093710
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© Georg Thieme Verlag KG Stuttgart · New York

On an Attempt to Treat Primary and Secondary Osteoporosis with Human Growth Hormone[*]

H.-P.  Kruse , F.  Kuhlencordt
  • Department Clinical Osteology, I. Medical University Clinic, Hamburg, Germany
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Three male patients with severe osteoporosis were treated with human growth hormone. One of them had a primary osteoporosis, the two others osteogenesis imperfecta. The duration of therapy was 8 to 15 months and average doses per day were 1.45 to 2.3 mg. While clinical and 47calcium kinetic data failed to prove marked influences of the treatment, histomorphometry of bone biopsies showed indisputable changes. There was an increase of periosteal new bone formation as well as of intracortical bone resorption, while at the same time the relative activity of osteoblasts on endosteal surfaces showed a significant increase.

Key words

Osteoporosis - Osteogenesis Imperfecta - Growth Hormone - Bone Histomorphometry

1 Supported by Deutsche Forschungsgemeinschaft, SFB 34 "Endocrinology".

1 Supported by Deutsche Forschungsgemeinschaft, SFB 34 "Endocrinology".