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Horm Metab Res 1975; 7(1): 59-61
DOI: 10.1055/s-0028-1093790
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© Georg Thieme Verlag KG Stuttgart · New York

Cellular Thyroid Autoimmune Reactions in Diabetes Mellitus[*]

G.  Delespesse , P. A. Bastenie , J.  Duchateau , B.  Kennes
  • Department of Medicine and Laboratories for Experimental Medicine and Immunology, Hôpital Saint-Pierre, Université de Bruxelles, Brussels, Belgium
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

The lymphoblastic transformation test (LTT) and the leucocyte migration inhibition test (LMT) induced by thyroglobulin have been assessed in 94 diabetic and 60 control subjects. In the diabetic population, these tests of cell-mediated-immunity were found to be present with a very high prevalence (respectively 21 and 39%) in contradistinction with the normal population (0 and 4%). In the diabetics there was no clear distinction between age and sex groups.

A primary defect of T lymphocyte function, apparently related to the diabetes, is postulated to explain these findings.

Key words

Leucocyte Migration Inhibition Test - Lymphoblastic Transformation Test - Autoimmune thyroiditis

1 Part of this work has been presented in a guest lecture at the Mayo Clinic (June 9, 1972).

1 Part of this work has been presented in a guest lecture at the Mayo Clinic (June 9, 1972).