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Horm Metab Res 1975; 7(1): 75-77
DOI: 10.1055/s-0028-1093794
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© Georg Thieme Verlag KG Stuttgart · New York

The Influence of Endogenous Corticosterone on the Activity of Tyrosine Transaminase in the Regenerating Rat Liver

L.  Desser-Wiest , C.  Zwintz , K.  Weiser
  • Institute of Cancer Research, University of Vienna, Austria
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Publication Date:
23 December 2008 (online)

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Abstract

Two maxima of corticosterone concentration in the serum of 2/3 hepatectomized male rats were observed. The first peak appeared immediately after the operation (controls: 17.8 (µg/100 ml serum, peak: 57.25 ± 6.9 µg per 100 ml serum) a second peak (38.0 ± 2.4 µg/100 ml serum) 15-18 hours later.

The half life of this hormone was found to be 4.5 hr, one hour longer than in shamoperated animals.

The first maximum of corticosterone in the serum was followed 3 hr later by an elevated activity of the tyrosine transaminase in the liver. After a second maximum of serum corticosterone concentration, a second stimulation of tyrosine transaminase in the liver was observed, again with a retardation of 3 hr.

The conclusion is drawn that endogenous corticosterone molecules are able to stimulate the activity of tyrosine transaminase in rat liver.

Key words

Liver Regeneration - Serum Corticosterone - Tyrosine Transaminase - Rats