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Horm Metab Res 1974; 6(6): 517-521
DOI: 10.1055/s-0028-1093801
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© Georg Thieme Verlag KG Stuttgart · New York

The Influence of Porcine Calcitonin Given Intragastrally on Restraint-Induced Gastric Ulcers in Pigs

J. P. Barlet
  • I.N.R.A., Theix, Beaumont, France
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Publication Date:
07 January 2009 (online)

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Abstract

Gastric ulcers, located in the fundic area, appeared in pigs restrained during a 24 hrs period. The development of these ulcers was prevented by porcine calcitonin (P-CT) given intramuscularly or intragastrally, at 5 hrs intervals, during the restraint period. P-CT increased significantly the pH of gastric secretion at the end of restraint. In non-restrained fasting pigs, P-CT given intragastrally strongly inhibited basal or gastrin-stimulated acid output. These results tend to indicate that P-CT prevented restraint-induced gastric ulcer in pigs, probably by inhibiting gastric HCl secretion.

Key words

Calcitonin - Gastric Secretion - Gastric Ulcer - Pig