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Horm Metab Res 1974; 6(6): 475-477
DOI: 10.1055/s-0028-1093806
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© Georg Thieme Verlag KG Stuttgart · New York

Inhibition by Diphenylhydantoin of the Diabetogenic Action of Streptozotocin[*]

R. J. Schimmel , D.  Graham
  • Department of Physiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Intravenous injection of diphenylhydantoin (DPH) (20 mg/ kg) 90 minutes prior to or 60 minutes after administration of streptozotocin to normal male rats was found to prevent the development of diabetes. However the rise in blood glucose concentrations 2 hours following administration of streptozotocin was not prevented by DPH; in fact when DPH was given 30 minutes before streptozotocin, the initial hyperglycemic response to streptozotocin was potentiated.

Key words

Diphenylhydantoin - Streptozotocin - Diabetes

1 This investigation was supported by a Research Grant from the Dreyfus Medical Foundation, New York, N.Y. 10004.

1 This investigation was supported by a Research Grant from the Dreyfus Medical Foundation, New York, N.Y. 10004.