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Horm Metab Res 1974; 6(2): 106-110
DOI: 10.1055/s-0028-1093891
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of the Local Anesthetics Procaine and Lidocaine on Insulin Secretion from Rabbit Pancreas Pieces

H.  Tjälve , D.  Popov , P.  Slanina
  • Department of Toxicology, University of Uppsala, Uppsala;
    Department of Pharmacology, Roy. Vet. College, Stockholm, Sweden
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Publikationsdatum:
07. Januar 2009 (online)

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Abstract

The effects of procaine and lidocaine on the insulin secretion from rabbit pancreas pieces were studied with a radioimmunological method. High concentrations of procaine and lidocaine were found to inhibit the insulin secretion, while low concentrations of procaine and lidocaine showed a stimulating effect. Atropine and hexamethonium did not block the inhibitory or most of the stimulatory effects of the local anesthetics, therefore the effects of the local anesthetics seem at least partially independent of the acetylcholine receptors. Effects on the calcium-movement in the β-cells and on serotonin-receptors in the islets are discussed as possible mechanisms of action.

Key words

Local Anesthetics - Insulin Secretion In Vitro