Effect of Alloxan on Calcium Metabolism in Mice and Rats[*]

Abstract

The effects of the diabetogenic drug alloxan on blood and urine levels of calcium within 24 hours after treatment were compared to those of parathyroid extract (PTE). Hypercalcemia and hypocalcuria followed PTE administration; by contrast, alloxan decreased blood calcium levels in both rats and mice, without affecting urinary calcium content.

Key words

Calcium - Parathyroid Hormone - Alloxan

1 Journal paper number 4158 from the Purdue Agricultural Experiment Station. This study was supported in part by Cooperative Research Fund 3267-46, from the Animal Husbandry Research Division, Agricultural Research Service, United States Department of Agriculture. These results form part of a thesis submitted by the senior author to the Faculty of the Graduate School of Purdue University in fulfillment of the requirements for the Master of Science Degree.

1 Journal paper number 4158 from the Purdue Agricultural Experiment Station. This study was supported in part by Cooperative Research Fund 3267-46, from the Animal Husbandry Research Division, Agricultural Research Service, United States Department of Agriculture. These results form part of a thesis submitted by the senior author to the Faculty of the Graduate School of Purdue University in fulfillment of the requirements for the Master of Science Degree.