Insulin Concentrations in Portal Venous and Peripheral Venous Blood in Man Following Administration of Glucose, Galactose, Xylitol and Tolbutamide

W. Berger; H. Göschke; J. Moppert; H. Künzli

doi:10.1055/s-0028-1093991

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1973; 5(1): 4-8
DOI: 10.1055/s-0028-1093991

Originals

Insulin Concentrations in Portal Venous and Peripheral Venous Blood in Man Following Administration of Glucose, Galactose, Xylitol and Tolbutamide[*]

W. Berger , H. Göschke , J. Moppert , H. Künzli

Departments of Medicine and Surgery, University of Basel, Kantonsspital, Basel, Switzerland

Abstract

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Abstract

By means of transumbilical portal catheterization immunoreactive insulin (IRI) concentrations in portal vein (POV) and in peripheral vein (PEV) were compared after administration of glucose, galactose, xylitol and tolbutamide. Fasting portal IRI concentration was about twice that found in PEV. After β-cell-stimulation the maximal IRI rise in POV was several times greater compared to PEV. Xylitol produced a significant IRI rise in POV but non in PEV. Thus, absence of IRI elevation in PEV does not exclude stimulation of IRI secretion. Factors affecting the difference between portal and peripheral venous IRI concentrations are discussed.

Key words

Transumbilical Portal Vein Catheterization - Portal Venous IRI - Galactose - Xylitol - Tolbutamide - Glucose

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Referenzen

1 These studies were supported in part by a grant from the Schweiz. Nationalfonds (348670). - Parts of the results of this work have been presented at the 7th Congress of the International Diabetes Federation, Buenos Aires 1970.