PDF herunterladen
Horm Metab Res 1972; 4(6): 426-433
DOI: 10.1055/s-0028-1094000
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Streptozotocin-Diabetes in the Chinese Hamster[*]

Blood Glucose and Structural Changes During the First 24 HoursE.  Wilander , L.  Boquist
  • Department of Pathology, University of Uppsala, and Department of Pathology, University of Umeå, Umeå, Sweden
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
07. Januar 2009 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Abstract

Intraperitoneal administration of 200 mg/kg body weight of streptozotocin to non-diabetic adult Chinese hamsters, evoked a triphasic blood glucose response. There was a hyperglycemic peak after 3 hours and a hypoglycemic phase with a minimum at 6 hours, after which time there was a rather rapid return to hyperglycemia. Light and electron microscopic examinations during the first 24 hours after the injection of streptozotocin showed pyknosis, vacuolization, marked degeneration and necrosis of the β-cells. Degenerative and necrotic changes were also seen in a few α2-cells. The results denote that in the Chinese hamster streptozotocin has an early and direct cytotoxic action on the β-cells and probably also on a few α2-cells.

Key words

Chinese Hamster - Streptozotocin - Pancreatic Islets - β-Cell Degeneration - α2-Cell Degeneration - Hyperglycemia

1 Supported by grants from the Swedish Medical Research Council (Project No. B72-12X-718-07A), the Swedish Diabetes Foundation and the Medical Faculty of Umeå.

1 Supported by grants from the Swedish Medical Research Council (Project No. B72-12X-718-07A), the Swedish Diabetes Foundation and the Medical Faculty of Umeå.