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Horm Metab Res 1972; 4(6): 467-469
DOI: 10.1055/s-0028-1094007
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© Georg Thieme Verlag KG Stuttgart · New York

Disappearance of Human Growth Hormone 125I in the Anephric Non-Uraemic and Uraemic Rat[*]

R.  Rabkin , B. L. Pimstone , T.  Marks , L.  Eales
  • M.R.C. Renal Metabolic Research Unit and Isotope Laboratory, Department of Medicine, University of Cape Town, South Africa
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Publication Date:
07 January 2009 (online)

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Abstract

The half disappearance time of HGH 125I was determined in rats at one or at twenty-four hours after nephrectomy or sham operation. The BUN and the T 1/2 of HGH, 125I in rats studied one hour after nephrectomy were not dissimilar to those of the sham operated controls. However, in rats rendered uraemic by nephrectomy twenty-four hours before the tracer study, the T 1/2 of the HGH 125I was significantly prolonged. Thus in this study the presence of a kidney was not obligatory for normal GH disappearance until significant uraemia developed. The kidney is therefore unlikely to be an important site for GH degradation even though rapid localization of this hormone has been shown to occur there.

Key words

GH Disappearance - Anephric Rats - Uraemia

1 Presented in part at the 2nd International Symposium on Growth Hormone, Milan, May 1971

1 Presented in part at the 2nd International Symposium on Growth Hormone, Milan, May 1971

2 Kindly provided by Dr. A.E. Wilhelmi through the National Pituitary Agency, U.S.A.