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Horm Metab Res 1972; 4(6): 484-488
DOI: 10.1055/s-0028-1094011
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© Georg Thieme Verlag KG Stuttgart · New York

Different Patterns of Thyrotropin (TSH)-Release, TSH-Resynthesis and of Corticosterone Depression After in vivo Administration of Thyrotropin-Releasing Hormone (TRH) and of an Isosteric Analog of TRH

H.  Steiner [*] , F.  Piva1 , G.  Gavazzi1 , R. O. Studer2 , D.  Gillessen2 , L.  Martini1
  • 1Department of Pharmacology, University of Milan, Italy
  • 2Department of Experimental Medicine and Chemistry, F. Hoffmann-La Roche, Basel, Switzerland
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

A comparison of the actions of Thyrotropin-releasing hormone (TRH) and of an analog, in which L-histidine is replaced by the isosteric amino acid L-β (pyrazolyl-3) alanine, in rats shows that the TSH-releasing effect of this analog is of shorter duration. Initially, however, there do not seem to exist major differences. The analog also induces a very rapid depression of free corticosterone (1 and 5 minutes after the intracarotid injection of 10 µg of the substance) as has been shown with TRH. The second corticosterone depression phase around 15 minutes after the injection is present with TRH only, but not with the analog.

Key words

Thyrotropin-Releasing Hormone (TRH) - TRH-Corticosterone Interrelationships - TSH-Bioassay - TRH-Analogs - Peripheral Effect of TRH - TSH-Resynthesis

1 This work has been done when Dr. Steiner was on leave from the F. Hoffmann-La Roche & Co., Ltd., Basel, in Dr. Martini's laboratory in Milan.