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Horm Metab Res 1972; 4(6): 500-505
DOI: 10.1055/s-0028-1094015
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© Georg Thieme Verlag KG Stuttgart · New York

Renin-Angiotensin System in Chronically Hypophysectomized Rats[*]

J. M. Rojo-Ortega [**] , M.  Chrétien [***] , J.  Genest
  • Clinical Research Institute of Montreal, Montreal, Quebec, Canada
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

The index of juxtaglomerular cell granularity (JGI), glucose-6-phosphate dehydrogenase (G6PD) activity in macula densa cells, renal renin content (RRC), and plasma renin concentration (PRC) were studied in chronically hypophysectomized (2 months) Sprague-Dawley rats under different experimental conditions. Hypophysectomy caused an increase of juxtaglomerular granularity, in macula densa G6PD activity, and in renal renin content, but not in plasma renin concentration. Daily administration of NaCl in the drinking water and injection of deoxycorticosterone prevented these changes in the hypophysectomized animals.

The results suggest that, in hypophysectomized rats, the juxtaglomerular apparatus is stimulated by some degree of negative sodium balance. For unknown reasons, however, renin release was not stimulated in the majority of the hypophysectomized animals.

Key words

Juxtaglomerular Cells - Macula Densa - Renal Renin Content - Plasma Renin Concentration - Hypophysectomy

1 This work was supported through grants from the Medical Research Council of Canada (MT-3213, MA-2547, MT-2915) and the Quebec Heart Foundation.

1 This work was supported through grants from the Medical Research Council of Canada (MT-3213, MA-2547, MT-2915) and the Quebec Heart Foundation.

2 Director, Laboratory of Experimental Hypertension and Electron Microscopy.

3 Director, Laboratory of Proteins and Polypeptide Hormones.