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Horm Metab Res 1972; 4(2): 107-110
DOI: 10.1055/s-0028-1094079
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© Georg Thieme Verlag KG Stuttgart · New York

Enzyme Patterns of the Energy-Linked Metabolism in Blood Cells of Human Diabetics

H. J. Mitzkat , K.  Wiegrefe , U.  Meyer
  • Arbeitsgruppe Diabetologie, Department Innere Medizin, Medizinische Hochschule Hannover, Germany
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Publikationsdatum:
07. Januar 2009 (online)

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Abstract

Enzyme patterns of the energy-linked metabolism in erythrocytes, leucocytes and blood platelets were studied in insulin-dependent human diabetics.

In erythrocytes an increase of the activity of G6PDH, 6PGDH, FDPase and ALD, of GAPDH, PGK, EN, LDH, MDH, T-IDH, ME, GOT, GPT was observed; in leucocytes increase of activity of G6PDH, FDPase, TIM, PGK, GAPDH, LDH and T-IDH and decrease of GPT is reported; in blood platelets GDH and MDH were significantly decreased.

There was no correlation between changes of enzyme activities and the quality of diabetes therapy; moreover, diabetics with good control were shown to have higher activities.

Key words

Enzyme Patterns - Energy-Linked Metabolism - Gluconeogenesis - Erythrocytes - Leucocytes - Blood Platelets - Insulin-Dependent Human Diabetics - Control of Diabetes Therapy