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Horm Metab Res 1972; 4(2): 119-121
DOI: 10.1055/s-0028-1094081
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© Georg Thieme Verlag KG Stuttgart · New York

Inhibition of the Estrogenic Activity of Triphenylethylene by 6-Aminochrysene and Other Inducers of Drug-Metabolizing Enzymes

N. P. Buu-Hoi [+] , H. T. Hieu
  • Centre National de la Recherche Scientifique, Paris, France
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Publikationsdatum:
07. Januar 2009 (online)

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Abstract

It was found that 6-Aminochrysene significantly reduces the estrogenic activity of triphenylethylene; this effort is most probably connected with the inducing activity of 6-aminochrysene towards microsomal drug-metabolizing enzymes, as a similar reducing effect was displayed by benz[a]anthracene and, to a lesser extent, by 13H-dibenzo[a,g]fluorene, both of which are also potent enzyme inducers.

Key words

6-Aminochrysene - Benz[a]anthracene - Triphenylethylene - Estrogenic Activity - Drug Metabolizing Enzymes

1 Deceased 28 January 1972