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Horm Metab Res 1972; 4(3): 133-135
DOI: 10.1055/s-0028-1094085
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© Georg Thieme Verlag KG Stuttgart · New York

Hyperproinsulinemia in Hypoglycemic Subjects[*]

W. C. Duckworth , A. E. Kitabchi
  • Laboratories of Endocrinology and Metabolism, Research Service, Veterans Administration Hospital, and Departments of Medicine and Biochemistry, University of Tennessee Medical Units, Memphis, Tennessee, USA
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Publication Date:
07 January 2009 (online)

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Abstract

Increased levels of plasma proinsulin were found in two subjects who developed hypoglycemia during an oral glucose tolerance test. Sixty minutes after glucose ingestion, proinsulin comprised more than 50% of the total immunoreactive substance. Repeat glucose tolerance tests in these individuals did not result in hypoglycemia, and proinsulin levels were not increased. These results suggest possible interrelationship between hyperproinsulinemia and hypoglycemia in these subjects.

Key words

Proinsulin - Insulin - Hypoglycemia

1 This work was supported in part by VA Research grants, by National Institute of Arthritis and Metabolic Diseases Grant AM 13102, and by Special Fellowship No. 5-FO3-AM-43023 (WCD) from the U.S. Public Health Service. A portion of this work was conducted through the Clinical Research Center of the University of Tennessee, supported by the National Institute of Health Grant RROO211.

1 This work was supported in part by VA Research grants, by National Institute of Arthritis and Metabolic Diseases Grant AM 13102, and by Special Fellowship No. 5-FO3-AM-43023 (WCD) from the U.S. Public Health Service. A portion of this work was conducted through the Clinical Research Center of the University of Tennessee, supported by the National Institute of Health Grant RROO211.