Increased Glomerular Clearance to (⁵¹CR) EDTA in Short-Term Insulin Treated Diabetics

Abstract

The plasma disappearance curve of (⁵¹ Cr) EDTA after a single injection of 15 µc/10 kg was studied in 23 diabetic subjects with a duration of diabetes of less than 10 years and with no clinical evidence of microangiopathy as compared to 23 non-diabetic control subjects. The mean renal clearance value, calculated according to the mathematical model provided by Sapirstein, Vidt, Mandel and Hanusek (1955), was significantly increased (p < 0.02) in the diabetic groups as opposed to the non-diabetic group: GFR: 131.4 (S.D.21.05) and 116.2 (S.D.19.21) ml/min/1.73 m² respectively. No statistically significant correlation could be demonstrated between the clearance values and the duration of diabetes, the age of the subject, insulin dosage, and the fasting blood-sugar.

Key words

⁵¹Cr-EDTA Clearance - Inulin Clearance - Functional Microangiopathy - Diabetic Microangiopathy - Glomerular Filtration - Capillary Permeability