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Horm Metab Res 1971; 3(5): 348-351
DOI: 10.1055/s-0028-1094121
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© Georg Thieme Verlag KG Stuttgart · New York

Inhibition by Thyrocalcitonin (Calcitonin) of the Cyclic AMP-Mediated Stimulation of Thymocyte Proliferation by Epinephrine[*]

J. F. Whitfield , J. P. MacManus , D. J. Gillan
  • Division of Biology, National Research Council of Canada, Ottawa, Canada
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Epinephrine stimulates the proliferation of rat thymic lymphocytes maintained in vitro by a cyclic AMP-mediated process. The mitogenic action of epinephrine is completely inhibited by low concentrations (6.0 to 8.0 mU per ml) of a highly purified sample of porcine thyrocalcitonin (calcitonin). In view of the fact that the same low levels of thyrocalcitonin are known to inhibit the cyclic AMP-mediated mitogenic action of vasopressin and the similar physiologically important mitogenic action of parathyroid hormone, it is proposed that thyrocalcitonin (calcitonin) may be a general regulator of cyclic AMP-controlled cell proliferation in vivo.

Key words

Stimulation of Thymic Lymphocyte (Thymocyte) Proliferation by Epinephrine - Inhibition of Epinephrine Action by Thyrocalcitonin (Calcitonin)

1 Issued as NRCC No. 12099

1 Issued as NRCC No. 12099