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Horm Metab Res 1971; 3(4): 277-278
DOI: 10.1055/s-0028-1094148
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© Georg Thieme Verlag KG Stuttgart · New York

In Vivo Cortisol-Induced Thymolysis without Hepatic Gluconeogenesis

J. F. Hofert
  • Department of Biochemistry, University of Nebraska College of Medicine, Omaha, Nebraska, U.S.A.
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Publication Date:
07 January 2009 (online)

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Abstract

The inhibitory effect of Cortisol administration on the incorporation of 3H-deoxycytidine into thymus DNA, as a measure of lymphocytolytic activity, was examined in adrenalectomized rats treated with tryptophan to prevent hepatic gluconeogenesis. The results show that a dose of tryptophan which totally blocks the effect of cortisol administration on liver glycogen deposition, has no influence on the cortisol-induced depression of incorporation of 3H-deoxycytidine into the thymus DNA.

Key words

Cortisol - Thymus - L-Tryptophan - Liver - Lymphocytolysis