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Horm Metab Res 1971; 3(2): 90-93
DOI: 10.1055/s-0028-1095033
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© Georg Thieme Verlag KG Stuttgart · New York

Effects of Cyclic AMP and Epinephrine on Insulin and Growth Hormone Secretion in Sheep

F.  Hertelendy
  • Department of Life Sciences, New Enterprise Division, Monsanto Company, St. Louis, Mo.; USA
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Intravenous infusion of dibutyryl 3',5'-AMP (0.1 mg/kg/ min) plus theophylline (0.13 mg/kg/min) for 20 min increased plasma concentration of growth hormone (GH) from 4.5 ± 0.9 to 22.4 ± 5.3 ng/ml and that of insulin from 13.1 ± 4.9 to 108 ± 27.6µU/ml of intact sheep. Concomitant administration of epinephrine (0.5µg/kg/ min.) abolished the GH response but did not supress the rise in plasma insulin. These studies support the concept of the involvement of the adenyl cyclase-cyclic AMP system in both GH and insulin secretion. However, the mechanism(s) mediating the effect of the cyclic nucleotide on GH secretion is different from its action on insulin release.

Key words

Insulin Secretion - GH-Secretion - Epinephrine - Dibutyryl-Cyclic AMP - Theophylline