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Horm Metab Res 1970; 2(6): 344-348
DOI: 10.1055/s-0028-1095051
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© Georg Thieme Verlag KG Stuttgart · New York

Contrasting Actions of Cis- and Trans-Clomiphene on the Release of FSH and FSH-RF in the Female Rat

Sylvia  Nagel , H.  Baier , H. -D. Taubert
  • Abteilung für gynäkologische Endokrinologie der Universitäts-Frauenklinik der Johann-Wolfgang-Goethe Universität Frankfurt am Main, Germany
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

An investigation was carried out on the effect of cis-clomiphene and trans-clomiphene upon the release of FSH in the oophorectomized, estrogen-progesterone blocked rat. Contrasting actions of the cis-isomers and trans-isomers could be shown. Cis-clomiphene was found to lower the hypothalamic content of FSH-RF and of pituitary FSH. As a consequence, there was a rise of plasma FSH in inverse proportions. The injection of 150 µg/rat proved to be most effective. When higher doses were given the level of plasma FSH fell, and the pituitary FSH and hypothalamic FSH-RF content rose.

Key words

Effect of Cis- and Trans-Clomiphene - Release of FSH and FSH-RF