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Horm Metab Res 1970; 2(5): 268-270
DOI: 10.1055/s-0028-1095056
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Action of Streptozotocin on Insulin and Glucagon Responses of Rat Islets

N.  Katsilambros [*] , Y. Abdel Rahman [*] , M.  Hinz , R.  Fußgänger , K. E. Schröder , K.  Straub , E. F. Pfeiffer [**]
  • Department of Endocrinology and Metabolism, Center of Internal Medicine and Pediatrics, University of Ulm, Germany
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

Experimental diabetes was produced in rats by i.v. streptozotocin injection (65 mg/kg). There was a significant increase in blood glucose and serum glucagon, while there was a significant decrease in serum insulin in diabetic animals as compared with controls. It is of interest that the glucagon elevation in the streptozotocin-induced diabetes in animals is of comparable magnitude to that seen in the ketoacidotic state of human diabetes.

Key words

Streptozotocin - Blood Glucose - Serum Insulin - Serum Glucagon - Arginine

1 Alexander von Humboldt Fellow

2 Supported by Deutsche Forschungsgemeinschaft, Bad Godesberg