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Horm Metab Res 1970; 2(5): 275-276
DOI: 10.1055/s-0028-1095058
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© Georg Thieme Verlag KG Stuttgart · New York

Potentiation of Diabetogenic Effect of L-Asparaginase by Prednisolone

A.  Khan , M.  Adachi , J. M. Hill
  • Department of Hematology, Wadley Institutes of Molecular Medicine, Dallas, Texas, USA
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

E. coli L-asparaginase 250 and 500 U/kg given in a single IV dose did not produce hyperglycemia or glycosuria in rabbits. Prednisolone 1 mg/kg/day administered for 14 days was also nondiabetogenic. A combination of L-asparaginase 500 U/kg with prednisolone was diabetogenic in all the animals. The results suggest that the two drugs act synergistically in producing the diabetogenic effect The clinical significance of these findings was discussed.

Key words

L-Asparaginase - Prednisolone - Synergism - Diabetogenic Effect - Enzyme