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Horm Metab Res 1970; 2(6): 318-322
DOI: 10.1055/s-0028-1095065
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© Georg Thieme Verlag KG Stuttgart · New York

Adrenergic Regulation of Basal Serum Glucose, NEFA and Insulin Levels[*]

J. J. Gagliardino , C. F. Bellone , I.  Doria , J. J. Sánchez , V.  Pereyra
  • Instituto de Fisiologiia and Cátedra de Medicina Interna B, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, and Comisión de Investigaciones Cientificasde la Provincia de Buenos Aires, La Plata, Argentina
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

The effect of alpha and beta adrenergic blocking agents on the basal serum levels of glucose, NEFA and insulin was studied in normal patients. It was shown that propranolol (β-blocking agent) produced a significant decrease in each of these variables. On the other hand, the opposite effect was obtained, except for glucose, when an α-blocking agent, phentolamine, was used. These findings suggest that circulating catecholamines may regulate the above-mentioned parameters through an equilibrium between two antagonistic effects.

Key words

Adrenergic Blocking Agents - Serum Insulin Regulation - Serum Glucose Regulation - Serum NEFA Regulation -Glucose-Insulin Interrelationship