PDF herunterladen
Horm Metab Res 1970; 2(2): 106-109
DOI: 10.1055/s-0028-1095096
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Dose-Response Comparsion Between Dexamethasone and 16-Methylene-6-Dehydrocortisol in the Short-Term Suppression Test

K. H. Gillich , H. L. Krüskemper
  • Abteilung II (Klinische Endokrinologie), Dept. Innere Medizin, Medizinische Hochschule Hannover, Germany
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
08. Januar 2009 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Abstract

In 24 healthy subjects a short-term suppression test was performed with 16-methylene-6-dehydrocortisol and, after an interval of at least 7 days, in 18 of these subjects with 0.5 to 3.0 mg of dexamethasone. The mean dose-response equivalent of dexamethasone : 16-methylene-6-dehydrocortisol was 1 : 22. Contrary to single administration of 3.0 mg of dexamethasone, 30 mg of 16-methylene-6-dehydrocortisol did not lead to complete suppression of the glucocorticoid function of the adrenal cortex. The fasting value of plasma Cortisol obtained after suppression is determined by the initial value and by the corticoid dose administered. Not more than a slight increase in suppression could be obtained by doses higher than, for instance, 1.5 mg of dexamethasone and 15 mg of 16-methylene-6-dehydrocortisol in healthy persons.

Key words

ACTH Suppression - Comparison of Dexamethasone and 16-Methylene-6-Dehydrocortisol