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Horm Metab Res 1970; 2(2): 72-75
DOI: 10.1055/s-0028-1095111
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© Georg Thieme Verlag KG Stuttgart · New York

Metabolic Effects of Butylbiguanide During Long Lasting Intravenous Glucose Infusion in Normal Human Subjects

F.  Gomez , J. P. Felber
  • Departement de Biochimie Clinique, Clinique Médicale Universitaire, Lausanne, Switzerland
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Publikationsdatum:
08. Januar 2009 (online)

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Abstract

In a previous report, butylbiguanide was found to increase the oral glucose tolerance in normal human subjects, but left the K-value unchanged during rapid intravenous tolerance tests.

The present report shows, that butylbiguanide increases the glucose tolerance of normal human subjects even when glucose is given intravenously over a long period of time (6-hour infusion).

The radioimmunological serum insulin (IRI) was not significantly changed.

The free fatty acids (FFA), however, were significantly lowered. This appeared to be a direct effect of the drug which could account for its blood glucose lowering action.

Key words

Intravenous Glucose Load - Butylbiguanide - Blood Sugar - Insulin Level - Plasma Free Fatty Acids