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Horm Metab Res 1969; 1(6): 276-281
DOI: 10.1055/s-0028-1095128
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© Georg Thieme Verlag KG Stuttgart · New York

The Effect of Dihydroergotamine on Growth Hormone-Induced Lipolysis in Dogs[*]

A.  Sirek , O. V. Sirek , A.  Niki , H.  Niki , K.  Przybylska
  • Department of Physiology, and Division of Teaching Laboratories, University of Toronto, Toronto, Canada
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

The usual reduction in the concentration of plasma free fatty acids (FFA) caused by a single intravenous injection of bovine growth hormone (GH) was abolished and replaced by an abrupt and steep rise when hypophysectomized dogs were pretreated with the alpha-adrenergic blocker dihydroergotamine (DHE). The acute hyperlipemic response was suppressible with puromycin. DHE was less effective in normal dogs, and did not modify the action of GH in insulin-deficient pancreatectomized and Houssay dogs. The serotonin antagonist BOL-148 did not change the response to GH; neither did the alpha-blocker phentolamine nor the beta-blocker Kö 592. DHE did not facilitate the effect of other lipolytic hormones such as adrenocorticotropin (ACTH) or thyrotropin (TSH). - The data indicate that DHE, by a mechanism probably not involving adrenergic receptors, facilitates lipolysis in response to a single injection of GH.

Key words

Plasma Free Fatty Acids - Growth Hormone - Dihydroergotamine - Normal - Hypophysectomized - Pancreatectomized - Houssay Dogs

1 Supported by the Medical Research Council of Canada, Grant No. 2280, and the Stephen B. Roman Foundation of Toronto.

1 Supported by the Medical Research Council of Canada, Grant No. 2280, and the Stephen B. Roman Foundation of Toronto.