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Horm Metab Res 1969; 1(5): 221-223
DOI: 10.1055/s-0028-1095138
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© Georg Thieme Verlag KG Stuttgart · New York

Disappearance Rate of Exogenous Insulin, Insulin Sensitivity, Responses of Plasma Growth Hormone and Cortisol and Urinary Epinephrine to Hypoglycemia in Prediabetic Subjects

E.  Cerasi , R.  Luft
  • Department of Endocrinology and Metabolism, Karolinska Hospital, Stockholm
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

Insulin sensitivity was found to be increased in a group of nine prediabetic subjects, indicating that some mechanism(s) compensates for the decreased ability to secrete insulin in response to glucose. Diabetes probably develops in prediabetic subjects when such a compensation is lost. The disappearance rate of insulin was of identical magnitude in the prediabetic and normal groups, indicating that the lower plasma insulin values in prediabetes do reflect a decreased secretion of insulin. No difference was found between the two groups regarding the responses of HGH, Cortisol and epinephrine to hypoglycemia.

Key words

Insulin Disappearance Rate - Insulin Sensitivity - Growth Hormone - Prediabetes