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Horm Metab Res 1969; 1(6): 255-257
DOI: 10.1055/s-0028-1095143
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© Georg Thieme Verlag KG Stuttgart · New York

Structural Comparison of Mammalian and Piscine Insulins

N. S. Track , K. B. M. Reid [*]
  • N.E.R.C. Fisheries Biochemical Research Unit Aberdeen, Aberdeen AB1 3RA, Scotland
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

From a structural comparison of mammalian and piscine insulin it seems that, besides the obvious differences in the amino acid sequences, there may be more subtle differences in the processes of chain initiation and activation of proinsulin between mammalian and piscine species. Also, it is suggested that the presence of two distinct insulin in some species may be the result of translational variation caused by ambiguous codons in the proinsulin messengers.

Key words

Mammalian Insulin - Piscine Insulin - Amino Acid Sequence - Proinsulin

1 Present addresses: N. S. Track, Instituts de Biologie Moléculaire et de Biochimie Clinique, Université de Genève, Geneva - Switzerland. K. B. M. Reid, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, England.