The Effect of Etilefrine (Effortil®) on Central Hemodynamics and Aorto- Coronary Bypass Blood Flow

Summary

In an attempt to elucidate the function of an aorto-coronary bypass in patients with coronary artery obliterative disease, intravenous injection of etilefrine was used to bring about variations of central hemodynamics. Etilefrine proved to cause a significant increase of cardiac output (OPA), mean systemic blood pressure and aorto-coronary bypass flow. Calculations of peripheral myocardial resistance showed a rather pronounced decrease in all vascular regions studied. There was no change of central venous pressure.

The decrease of the myocardial vascular resistance, as shown by the increase of aorto-coronary bypass flow, is indicative of the myocardial vascular capacity. Hence, it may be of value as a prognostic test.

Key-Words:

Etilefrine - Coronary blood flow - Cardiac output - Central venous pressure - Aorto-coronary bypass