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Planta Med 1979; 35(4): 360-365
DOI: 10.1055/s-0028-1097230
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Isolement de l'acide aristolochique de deux aristoloches malgaches. Détermination de sa cytotoxicité sur cellules végétales. Comparaison avec les cellules animales

Isolation of Aristolochic Acid from two Madagascar Aristolochiaceae. Determination of its Toxicity on Vegetal Cells. Comparison with Animal CellsC. Moretti1 , M. Rideau2 , J. C. Chénieux2 , C. Viel1
  • 1Centre d'Etudes et de Recherches de Chimie Organique Appliquée, CNRS, 2 rue Henry Dunant, 94320 Thiais (France).
  • 2Laboratoire de Biologie Végétale et Cellulaire, Faculté de Pharmacie, 2 bis Boulevard Tonnelle, 37000 Tours (France).
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Publication History

Publication Date:
13 January 2009 (online)

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Abstract

Isolation of aristolochic acid I and of a small amount of aristolochic acid D, 2 from Aristolochia acuminata Lamarck and from Aristolochia multiflora DUCHARTRE.

The cytotoxicity of aristolochic acid on animal tumoral cells is found again in vitro on vegetal cells, the tumoral cells of Crown–gall being the most sensitive to the action of the acid.

Key Word Index

Aristolochiaceae - Aristolochia acuminata - Aristolochia multiflora - Aristolochic acid - Cytotoxicity