A Bioassay of Antimitotic Alkaloids of Catharanthus roseus

M. M. El–Merzabani; A. A. El–Aaser; A. K. El–Duweini; A. M. El–Masry

doi:10.1055/s-0028-1097246

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Planta Med 1979; 36(5): 87-90
DOI: 10.1055/s-0028-1097246

Research Articles

A Bioassay of Antimitotic Alkaloids of Catharanthus roseus

M. M. El–Merzabani, A. A. El–Aaser, A. K. El–Duweini¹ , A. M. El–Masry²

The Cancer Institute, Cairo University.

1 Academy of Scientific Research and Technology, Egypt. 2 Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Cairo University.

Further Information

Publication History

Publication Date:
13 January 2009 (online)

Also available at

PDF Download Permissions and Reprints

Abstract

This paper describes a bioassay for the quantitative determination of the antimitotic principle(s) present in the periwinkle plant using mice bearing Ehrlich ascites carcinoma (EAC). The method proved accurate, specific, simple and cheap. It could be of great value for the phytochemical screening of plants intended to discover new active compounds capable of arresting mitosis of tumor cells in the metaphase.

Key Word Index

Catharanthus roseus - Antimitotic Activity - Ehrlich Ascites Carcinoma