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Planta Med 1979; 36(7): 193-195
DOI: 10.1055/s-0028-1097268
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Inhibition of 3',5'–AMP Phosphodiesterase by Biflavonoids and Xanthones

A. Beretz1 , M. Joly1 , J. C. Stoclet2 , R. Anton1
  • 1Laboratoire de Pharmacognosie,
  • 2Laboratoire de Pharmacodynamie, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg.
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Publikationsdatum:
13. Januar 2009 (online)

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Abstract

Biflavonoids and xanthones were assayed for their ability to inhibit the breakdown of cyclic AMP by a commercial beef–heart phosphodiesterase. Most of the biflavonoids were active in the micromolar range, while amento–flavone was ten times as potent; two xanthones had I50 values of about 30 μM.

Key Word Index

Flavonoids - Biflavonoids - Xanthones - CAMP Phosphodiesterase Inhibitors